Some of the 'aha' insights that scientists strive for may have to await the emergence of post-human intellects.
— Martin Rees
A monkey is unaware that atoms exist. Likewise, our brainpower may not stretch to the deepest aspects of reality. The bedrock nature of space and time, and the structure of our entire universe, may remain 'open frontiers' beyond human grasp.
The first voyagers to the stars will be creatures whose life cycle is matched to the voyage: the aeons involved in traversing the galaxy are not daunting to immortal beings. By the end of the third millennium, travel to other stars could be technically feasible. But would there be sufficient motive?
The stupendous time spans of the evolutionary past are now part of common culture (though maybe not in the United States Bible Belt, nor in parts of the Islamic world). Most people are at ease with the idea that our present biosphere is the outcome of four billion years of Darwinian evolution.
Advances in technology - hugely beneficial though they are - render us vulnerable in new ways. For instance, our interconnected world depends on elaborate networks: electric power grids, air traffic control, international finance, just-in-time delivery, and so forth.
The advance of science spares us from irrational dread.
Everything, however complicated - breaking waves, migrating birds, and tropical forests - is made of atoms and obeys the equations of quantum physics. But even if those equations could be solved, they wouldn't offer the enlightenment that scientists seek. Each science has its own autonomous concepts and laws.
There are strong reasons for believing that space goes on beyond the limits of our observational horizon. There are strong reasons because if you look in opposite directions, conditions are the same to within one part in 100,000. So if we are part of some finite structure then, if the gradient is so shallow, it is likely to go on much further.
Not even the most secular among us can fail to be uplifted by Christianity's architectural legacy - the great cathedrals. These immense and glorious buildings were erected in an era of constricted horizons, both in time and in space.
Most practising scientists focus on 'bite-sized' problems that are timely and tractable. The occupational risk is then to lose sight of the big picture.
General writing about science, even if we do it badly, helps us to see our work in perspective and broadens our vision.
The next humans to walk on the moon may be Chinese. Only China seems to have the resources, the dirigiste government, and the willingness to undertake a risky Apollo-style programme. If Americans or Europeans venture to the moon and beyond, this will have to be in a very different style and with different motives.
Perhaps future space probes will be plastered in commercial logos, just as Formula One cars are now. Perhaps Robot Wars in space will be a lucrative spectator sport. If humans venture back to the moon, and even beyond, they may carry commercial insignia rather than national flags.
There is an ever-widening gap between what science allows and what we should actually do. There are many doors science can open that should be kept closed, on prudential or ethical grounds.
If we ever established contact with intelligent life on another world, there would be barriers to communication. First, they would be many light years away, so signals would take many years to reach them: there would be no scope for quick repartee. There might be an IQ gap.
During the 20th century, we came to understand that the essence of all substances - their colour, texture, hardness and so forth - is set by their structure, on scales far smaller even than a microscope can see. Everything on Earth is made of atoms, which are, especially in living things, combined together in intricate molecular assemblages.
It might seem paradoxical that the biggest scientific instruments of all are needed in order to probe the very smallest things in nature. The micro-world is inherently 'fuzzy' - the sharper the detail we wish to study, the higher the energy that is required and the bigger the accelerator that is needed.
Some things, like the orbits of the planets, can be calculated far into the future. But that's atypical. In most contexts, there is a limit. Even the most fine-grained computation can only forecast British weather a few days ahead. There are limits to what can ever be learned about the future, however powerful computers become.
Post-human intelligence will develop hypercomputers with the processing power to simulate living things - even entire worlds. Perhaps advanced beings could use hypercomputers to surpass the best 'special effects' in movies or computer games so vastly that they could simulate a world, fully, as complex as the one we perceive ourselves to be in.
If we do find ET, we will at least have something in common with them. They may live on planet Zog and have seven tentacles, but they will be made of the same kinds of atoms as us. If they have eyes, they will gaze out on the same cosmos as we do. They will, like us, trace their origins back to a 'Big Bang' 13.8 billion years ago.
Science is the one culture that's truly global - protons, proteins and Pythagoras's Theorem are the same from China to Peru. It should transcend all barriers of nationality. It should straddle all faiths, too.
The atmospheric CO2 concentration is rising - mainly due to the burning of fossil fuels. It's agreed that this build-up will, in itself, induce a long-term warming trend, superimposed on all the other complicated effects that make climate fluctuate.
As regards my own 'philosophy,' I continue to be inspired by the music, liturgy and architectural tradition of the Anglican Church in which I was brought up. No one can fail to be uplifted by great cathedrals - such as that at Ely, near my home in Cambridge.
Indeed, the night sky is the part of our environment that's been common to all cultures throughout human history. All have gazed up at the 'vault of heaven' and interpreted it in their own way.
I've got no religious beliefs at all.
Just as there are many Jews who keep the Friday ritual in their home despite describing themselves as atheists, I am a 'tribal Christian,' happy to attend church services.
The Blair government perhaps ranks as the best the U.K. has had for 50 years. It cannot match the scale of Attlee's reforms, but has a fine record of constitutional reform and economic competence. In my own areas - science and innovation - there have been well-judged and effective changes.
The scientific issues that engage people most are the truly fundamental ones: is the universe infinite? Is life just a sideshow in the cosmos? What happened before the Big Bang? Everyone is flummoxed by such questions, so there is, in a sense, no gulf between experts and the rest.
It would be sad if the expertise built up during the 40 years of the U.S. and Russian manned programmes were allowed to dissipate. But abandoning the shuttle, and committing to new launch vehicles and propulsion systems, is actually a prerequisite for a vibrant manned programme.
Darwin and his successors taught us how our biosphere evolved, and thereby transformed our conception of humanity's place in nature. In the twenty-first century, space scientists are setting Darwin in a grander cosmic context - probing the origins of Earth, stars, atoms and the universe itself.
We do not fully understand the consequences of rising populations and increasing energy consumption on the interwoven fabric of atmosphere, water, land and life.
We are 'nuclear waste' from the fuel that makes stars shine; indeed, each of us contains atoms whose provenance can be traced back to thousands of different stars spread through our Milky Way.
Most theorists suspect that space has an intricate structure - that it is 'grainy' - but that this structure is on a much finer scale than any known subatomic particle. The structure could be of an exotic kind: extra dimensions, over and above the three that we are used to (up and down, backward and forward, left and right).
Given the scale of issues like global warming and epidemic disease, we shouldn't underestimate the importance of a can-do attitude to science rather than a can't-afford-it attitude.
Indeed, our everyday world presents intellectual challenges just as daunting as those of the cosmos and the quantum, and that is where 99 per cent of scientists focus their efforts. Even the smallest insect, with its intricate structure, is far more complex than either an atom or a star.
Space and time may have a structure as intricate as the fauna of a rich ecosystem, but on a scale far larger than the horizon of our observations.
Space doesn't offer an escape from Earth's problems. And even with nuclear fuel, the transit time to nearby stars exceeds a human lifetime. Interstellar travel is therefore, in my view, an enterprise for post-humans, evolved from our species not via natural selection, but by design.
The practical case for manned spacef light gets ever-weaker with each advance in robots and miniaturisation - indeed, as a scientist or practical man, I see little purpose in sending people into space at all. But as a human being, I'm an enthusiast for manned missions.
The scientists who attack mainstream religion, rather than striving for peaceful coexistence with it, damage science, and also weaken the fight against fundamentalism.
The bedrock nature of space and time and the unification of cosmos and quantum are surely among science's great 'open frontiers.' These are parts of the intellectual map where we're still groping for the truth - where, in the fashion of ancient cartographers, we must still inscribe 'here be dragons.'
There are lots of ideas which extend the Copernican principle one step further. We went from the solar system to the galaxy to zillions of galaxies and now to realising even that isn't all there is.
If you are teaching Muslim sixth formers in a school, and you tell them they can't have their God and Darwin, there is a risk they will choose their God and be lost to science.
It is astonishing that human brains, which evolved to cope with the everyday world, have been able to grasp the counterintuitive mysteries of the cosmos and the quantum.
The lives of those such as Charles Darwin and Albert Einstein are plainly of interest in their own right, as well as for the light they shed on the way these great scientists worked. But are 'routine' scientists as fascinating as their science? Here I have my doubts.
When scientists are asked what they are working on, their response is seldom 'Finding the origin of the universe' or 'Seeking to cure cancer.' Usually, they will claim to be tackling a very specific problem - a small piece of the jigsaw that builds up the big picture.
Ironically, it is only when disaster strikes that the shuttle makes the headlines. Its routine flights attracted less media interest than unmanned probes to the planets or the images from the Hubble Telescope. The fate of Columbia (like that of Challenger in 1986) reminded us that space is still a hazardous environment.
The challenge of global warming should stimulate a whole raft of manifestly benign innovations - for conserving energy and generating it by 'clean' means (biofuels, innovative renewables, carbon sequestration, and nuclear fusion).
Collective human actions are transforming, even ravaging, the biosphere - perhaps irreversibly - through global warming and loss of biodiversity.
There are at least as many galaxies in our observable universe as there are stars in our galaxy.
The Cern laboratory in Geneva was set up in 1955 to bring together European scientists who wished to pursue research into the nuclear and sub-nuclear world. Physicists then had greater clout than other scientists because the memory of their role in the Second World War was fresh in people's minds.