A great hope gets crushed every time someone reminds us that happiness can be neither assumed nor earned; that we are all prisoners of our own flawed brains; that the ultimate aloneness in each of us is, finally, inviolable.

It's important to say that depression has biological underpinnings, and that while medications do not seem to create irreversible changes in the brain, repeated depressive episodes do.

I'm endlessly intrigued by stories, and I love helping someone to formulate his or her story. I can drift off when I'm reading pure abstraction, but the narratives of human lives hold my attention every time.

Andrew Solomon Quotes