We have found that fusions of GFP with the RING finger domains of certain E3 ubiquitin ligases creates an unstable GFP. We have used unstable GFP to learn how disruption of microtubules in the touch receptor neurons causes a generalized reduction in protein levels in the cells.

What I am primarily is a neurogeneticist: I use genetics to study problems in neurobiology. The one problem I study primarily... understanding of the sense of touch.

I do think of this prize as the GFP prize, and I happen to fortunately be one of the people that goes along for the ride.

Martin Chalfie Quotes