When I was a kid, my grandparents were Greek immigrants on my father's side. My grandfather used to read me Greek myths, in which there are a great many goddesses and stories of strong women. And I was entranced by them. Then I started reading science fiction very young, and I loved it.
Our worst instincts as human beings have to do with our carelessness with natural resources, and when the body itself becomes just one more of those resources, how will we treat it? Will we treat it with such indifference and with such depersonalization that it becomes more like a very fancy car than a repository of the self?
My favorite Asimov works were the 'Foundation' books because the concept, at the time, was crazy, but psycho-history has now turned out to be an actual real thing. You can predict the actions of large groups of people once you understand, for lack of a better way to put it, their way of existing and their prejudices.